

| Каталожный номер | HP137014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human DZIP1 Polyclonal Antibody (HP137014) is a rabbit polyclonal antibody detecting DZIP1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human DZIP1 (Ser66-Asp114). | ||||||||
| Цель | DAZ-interacting protein 1/2, DZIP1, Zinc finger protein DZIP1, DZIP, KIAA0996, DZIP2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q86YF9 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Cilium assembly protein DZIP1 is a ~98 kDa protein. Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm. 1. Glazer, AM. et al. (2010) Developmental biology 337, 148-56. PMID: 19852954 2. Wang, C. et al. (2013) The Journal of biological chemistry 288, 29518-29. PMID: 23955340 3. Zhang, B. et al. (2017) The Journal of biological chemistry 292, 1351-1360. PMID: 27979967 4. Lv, M. et al. (2020) Journal of medical genetics 57, 445-453. PMID: 32051257 5. Toomer, KA. et al. (2019) Science translational medicine 11. PMID: 31118289 | ||||||||
| Примечание | For research use only. |
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