Anti-Human ERCC2 Polyclonal Antibody (HB888014)

Name: Anti-Human ERCC2 Polyclonal Antibody
Brand: abinScience
SKU: HB888014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Datasheet
SDS

Vista general

Número de catálogo

HB888014

Descripción

Anti-Human ERCC2 Polyclonal Antibody (HB888014) is a rabbit polyclonal antibody detecting ERCC2. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human ERCC2 (Cys489-Leu760).

Objetivo

BTF2 p80, Basic transcription factor 2 80 kDa subunit, CXPD, DNA 5'-3' helicase XPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, EC:5.6.2.3, ERCC2, General transcription and DNA repair factor IIH helicase subunit XPD, TFIIH 80 kDa subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH p80, TFIIH subunit XPD, XPD, XPDC, Xeroderma pigmentosum group D-complementing protein

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P18074

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) is a ~86 kDa protein. ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognizes damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II.

1. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769

2. Sung, P. et al. (1993) Nature 365, 852-5. PMID: 8413672

3. Coin, F. et al. (1998) Nature genetics 20, 184-8. PMID: 9771713

4. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882

5. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626

6. Mathieu, N. et al. (2013) Current biology : CB 23, 204-12. PMID: 23352696

7. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human ERCC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human ERCC2 Polyclonal Antibody (HB888014)

Vista general

Imágenes

Referencias

Datasheet

SDS