Anti-Human ERCC2 Polyclonal Antibody (HB888014)

Name: Anti-Human ERCC2 Polyclonal Antibody
Brand: abinScience
SKU: HB888014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HB888014

説明

Anti-Human ERCC2 Polyclonal Antibody (HB888014) is a rabbit polyclonal antibody detecting ERCC2. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human ERCC2 (Cys489-Leu760).

ターゲット

BTF2 p80, Basic transcription factor 2 80 kDa subunit, CXPD, DNA 5'-3' helicase XPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, EC:5.6.2.3, ERCC2, General transcription and DNA repair factor IIH helicase subunit XPD, TFIIH 80 kDa subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH p80, TFIIH subunit XPD, XPD, XPDC, Xeroderma pigmentosum group D-complementing protein

エンドトキシンレベル

Please contact with the lab for this information.

精製

Purified by antigen affinity column.

アクセッション番号

P18074

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) is a ~86 kDa protein. ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognizes damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II.

1. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769

2. Sung, P. et al. (1993) Nature 365, 852-5. PMID: 8413672

3. Coin, F. et al. (1998) Nature genetics 20, 184-8. PMID: 9771713

4. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882

5. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626

6. Mathieu, N. et al. (2013) Current biology : CB 23, 204-12. PMID: 23352696

7. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107

注意事項

For research use only

イメージ

参考文献

データシート

Anti-Human ERCC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human ERCC2 Polyclonal Antibody (HB888014)

概要

イメージ

参考文献

データシート

SDS