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Anti-Human ERCC3 Polyclonal Antibody (HB951014)

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Vista general
Número de catálogoHB951014
Descripción
Anti-Human ERCC3 Polyclonal Antibody (HB951014) is a rabbit polyclonal antibody detecting ERCC3. Suitable for Human, Rat, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ERCC3 (Lys504-Glu725).
Objetivo BTF2 p89, Basic transcription factor 2 89 kDa subunit, DNA 3'-5' helicase/translocase XPB, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, EC:5.6.2.4, ERCC3, General transcription and DNA repair factor IIH helicase/translocase subunit XPB, TFIIH 89 kDa subunit, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH p89, TFIIH subunit XPB, XPB, XPBC, Xeroderma pigmentosum group B-complementing protein
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P19447
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

General transcription and DNA repair factor IIH helicase/translocase subunit XPB (ERCC3) is a ~89 kDa protein. ATP-dependent 3'-5' DNA helicase/translocase. Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor.

1. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626
2. He, Y. et al. (2016) Nature 533, 359-65. PMID: 27193682
3. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107
4. Schaeffer, L. et al. (1993) Science (New York, N.Y.) 260, 58-63. PMID: 8465201
5. Hwang, JR. et al. (1996) The Journal of biological chemistry 271, 15898-904. PMID: 8663148
6. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882
7. van Vuuren, AJ. et al. (1994) The EMBO journal 13, 1645-53. PMID: 8157004
10. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human ERCC3 Polyclonal Antibody

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