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| カタログ番号 | HB951014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ERCC3 Polyclonal Antibody (HB951014) is a rabbit polyclonal antibody detecting ERCC3. Suitable for Human, Rat, and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ERCC3 (Lys504-Glu725). | ||||||||
| ターゲット | BTF2 p89, Basic transcription factor 2 89 kDa subunit, DNA 3'-5' helicase/translocase XPB, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, EC:5.6.2.4, ERCC3, General transcription and DNA repair factor IIH helicase/translocase subunit XPB, TFIIH 89 kDa subunit, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH p89, TFIIH subunit XPB, XPB, XPBC, Xeroderma pigmentosum group B-complementing protein | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P19447 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | General transcription and DNA repair factor IIH helicase/translocase subunit XPB (ERCC3) is a ~89 kDa protein. ATP-dependent 3'-5' DNA helicase/translocase. Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor. 1. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626 2. He, Y. et al. (2016) Nature 533, 359-65. PMID: 27193682 3. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107 4. Schaeffer, L. et al. (1993) Science (New York, N.Y.) 260, 58-63. PMID: 8465201 5. Hwang, JR. et al. (1996) The Journal of biological chemistry 271, 15898-904. PMID: 8663148 6. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882 7. van Vuuren, AJ. et al. (1994) The EMBO journal 13, 1645-53. PMID: 8157004 10. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769 | ||||||||
| 注意事項 | For research use only |
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