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| カタログ番号 | HF610013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1800 | ||||
| ターゲット | Stuart factor, Stuart-Prower factor, Coagulation factor X, F10 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P00742 | ||||
| RRID | Anti-Human F10/Factor X Antibody (SAA1800) (abinScience Cat# HF610013, RRID:AB_3727562) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Coagulation factor X (F10) is a ~54 kDa protein. Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner. Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues. 1. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427 2. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037 3. Bukowska, A. et al. (2013) European journal of pharmacology 718, 114-23. PMID: 24041930 4. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593 5. D'Alessandro, E. et al. (2021) Cells 10. PMID: 34831181 6. Borensztajn, K. et al. (2008) The American journal of pathology 172, 309-20. PMID: 18202198 7. Shrivastava, G. et al. (2022) ImmunoHorizons 6, 373-383. PMID: 35738824 8. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human F10/Factor X Antibody (SAA1800)
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