Anti-F10/Factor X Polyclonal Antibody (HF610014)

Name: Anti-F10/Factor X Polyclonal Antibody
Brand: abinScience
SKU: HF610014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
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Overview

Catalog No.

HF610014

Description

Anti-F10/Factor X Polyclonal Antibody (HF610014) is a rabbit polyclonal antibody detecting F10 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human F10/Factor X (Leu24-Lys488).

Target

Stuart factor, Stuart-Prower factor, Coagulation factor X, F10

Purification

Purified by antigen affinity column.

Accession

P00742

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Coagulation factor X (F10) is a ~54 kDa protein. Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner. Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues.

1. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427

2. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037

3. Bukowska, A. et al. (2013) European journal of pharmacology 718, 114-23. PMID: 24041930

4. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593

5. D'Alessandro, E. et al. (2021) Cells 10. PMID: 34831181

6. Borensztajn, K. et al. (2008) The American journal of pathology 172, 309-20. PMID: 18202198

7. Shrivastava, G. et al. (2022) ImmunoHorizons 6, 373-383. PMID: 35738824

8. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208

Note

For research use only.

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