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| カタログ番号 | HY575014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human FBXO45 Polyclonal Antibody (HY575014) is a rabbit polyclonal antibody detecting FBXO45 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FBXO45 (Ser41-Gly286). | ||||||||
| ターゲット | F-box/SPRY domain-containing protein 1, F-box only protein 45, hFbxo45, FBXO45, FBX45 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P0C2W1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | F-box/SPRY domain-containing protein 1 (FBXO45) is a ~30 kDa protein. Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but also plays an important role in assembly of the complex. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism. Plays a role in the regulation of neurotransmission at mature neurons. 1. Desbois, M. et al. (2018) The Journal of biological chemistry 293, 13897-13909. PMID: 29997255 2. Richter, KT. et al. (2020) Cell death and differentiation 27, 758-772. PMID: 31285543 3. Tsai, M. et al. (2022) The Journal of biological chemistry 298, 102698. PMID: 36379255 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-FBXO45 polyclonal antibody at FBXO45 on various samples.
Lane 1: Mouse brain lysate
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