

| Каталожный номер | HD574014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human FKTN Polyclonal Antibody (HD574014) is a rabbit polyclonal antibody detecting FKTN. Suitable for Human.
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human FKTN (Cys250-Tyr461). | ||||||||
| Цель | EC:2.7.8.-, FCMD, FKTN, Fukutin, Fukuyama-type congenital muscular dystrophy protein, Ribitol-5-phosphate transferase, Ribitol-5-phosphate transferase FKTN | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O75072 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Ribitol-5-phosphate transferase FKTN is a ~53 kDa protein. Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable). 1. Kanagawa, M. et al. (2016) Cell reports 14, 2209-2223. PMID: 26923585 2. Gerin, I. et al. (2016) Nature communications 7, 11534. PMID: 27194101 3. Nishihara, R. et al. (2018) Biochemical and biophysical research communications 497, 1025-1030. PMID: 29477842 4. Xiong, H. et al. (2006) Biochemical and biophysical research communications 350, 935-41. PMID: 17034757 5. Willer, T. et al. (2014) eLife 3. PMID: 25279699 | ||||||||
| Примечание | For research use only |
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