Human FKTN Recombinant Protein (N-His) (HD574012)

Name: Human FKTN Recombinant Protein (N-His)
Brand: abinScience
SKU: HD574012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD574012
Description	Recombinant Human FKTN Protein, N-His (HD574012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	O75072
Protein length	Cys250-Tyr461
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.8.-, FCMD, FKTN, Fukutin, Fukuyama-type congenital muscular dystrophy protein, Ribitol-5-phosphate transferase, Ribitol-5-phosphate transferase FKTN
Background	Ribitol-5-phosphate transferase FKTN is a ~53 kDa protein. Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable). 1. Kanagawa, M. et al. (2016) Cell reports 14, 2209-2223. PMID: 26923585 2. Gerin, I. et al. (2016) Nature communications 7, 11534. PMID: 27194101 3. Nishihara, R. et al. (2018) Biochemical and biophysical research communications 497, 1025-1030. PMID: 29477842 4. Xiong, H. et al. (2006) Biochemical and biophysical research communications 350, 935-41. PMID: 17034757 5. Willer, T. et al. (2014) eLife 3. PMID: 25279699
Note	For research use only

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Datasheet

Human FKTN Recombinant Protein (N-His).pdf

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Human FKTN Recombinant Protein (N-His) (HD574012)

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