Anti-Human FKTN Polyclonal Antibody (HD574014)

Name: Anti-Human FKTN Polyclonal Antibody
Brand: abinScience
SKU: HD574014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HD574014

Description

Anti-Human FKTN Polyclonal Antibody (HD574014) is a rabbit polyclonal antibody detecting FKTN. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FKTN (Cys250-Tyr461).

Target

EC:2.7.8.-, FCMD, FKTN, Fukutin, Fukuyama-type congenital muscular dystrophy protein, Ribitol-5-phosphate transferase, Ribitol-5-phosphate transferase FKTN

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O75072

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Ribitol-5-phosphate transferase FKTN is a ~53 kDa protein. Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable).

1. Kanagawa, M. et al. (2016) Cell reports 14, 2209-2223. PMID: 26923585

2. Gerin, I. et al. (2016) Nature communications 7, 11534. PMID: 27194101

3. Nishihara, R. et al. (2018) Biochemical and biophysical research communications 497, 1025-1030. PMID: 29477842

4. Xiong, H. et al. (2006) Biochemical and biophysical research communications 350, 935-41. PMID: 17034757

5. Willer, T. et al. (2014) eLife 3. PMID: 25279699

Note

For research use only

Images

References

Datasheet

Anti-Human FKTN Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human FKTN Polyclonal Antibody (HD574014)

Overview

Images

References

Datasheet

SDS

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