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Anti-Human FXR1 Polyclonal Antibody (HW827014)

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Número de catálogoHW827014
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human FXR1 (Met1-Ala173).
Objetivo Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1
Purificación Purified by antigen affinity column.
Número de acceso P51114
RRID Anti-Human FXR1 Polyclonal Antibody (abinScience Cat# HW827014, RRID:AB_3730721)
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

RNA-binding protein FXR1 is a ~69 kDa protein. mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids. Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site.

1. Vasudevan, S. et al. (2007) Cell 128, 1105-18. PMID: 17382880
2. Say, E. et al. (2010) Molecular cell 38, 236-49. PMID: 20417602
3. Herman, AB. et al. (2018) Cell reports 24, 1176-1189. PMID: 30067974
4. George, J. et al. (2021) Cell reports 37, 109934. PMID: 34731628
5. Ling, H. et al. (2022) Oncogene 41, 4433-4445. PMID: 35989368
6. Datta, C. et al. (2022) Science advances 8, eabo1304. PMID: 36306353
9. Fischer-Kešo, R. et al. (2014) Molecular and cellular biology 34, 4244-56. PMID: 25225333
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human FXR1 Polyclonal Antibody

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