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| カタログ番号 | HW668014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GATM Polyclonal Antibody (HW668014) is a rabbit polyclonal antibody detecting GATM in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GATM (Glu76-Asp423). | ||||||||
| ターゲット | Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, GATM, Transamidinase, AGAT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P50440 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glycine amidinotransferase, mitochondrial (GATM) is a ~48 kDa protein. Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable). 1. Cullen, ME. et al. (2006) Circulation 114, I16-20. PMID: 16820567 2. DesRoches, CL. et al. (2016) Human mutation 37, 926-32. PMID: 27233232 3. Sinn, M. et al. (2022) Scientific reports 12, 22088. PMID: 36543883 4. Gross, MD. et al. (1986) Archives of biochemistry and biophysics 251, 747-55. PMID: 3800397 5. Fritsche, E. et al. (1997) European journal of biochemistry 247, 483-90. PMID: 9266688 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-GATM1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse kidney lysate
Lane 2: Mouse pancears lysate
Lane 3: Rat kidney lysate
Lane 4: Rat pancears lysat
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