Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

Name: Anti-Human GFR alpha-like Recombinant Antibody (SAA1999)
Brand: abinScience
SKU: HS720013
Price: 110 USD
Availability: InStock

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Especificación:

20ug
50ug
100ug
1mg

Número:

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Datasheet
SDS

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Número de catálogo

HS720013

Descripción

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013) is a human monoclonal antibody detecting GFR alpha-like in ELISA, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, WB

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

IgG1

ID de clon

SAA1999

Objetivo

C6orf144, GDNF family receptor alpha-like, GFRAL

Nivel de endotoxinas

< 10 EU/mg as determined by LAL method.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q6UXV0

RRID

Anti-Human GFRAL Antibody (SAA1999) (abinScience Cat# HS720013, RRID:AB_3727911)
_x005F_x000D_

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

GDNF family receptor alpha-like (GFRAL) is a ~44 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.

1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

5. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958

7. Li, J. et al. (2019) eLife 8. PMID: 31535977

Nota

For research use only.

Isotype Control

Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human GFRAL Antibody (SAA1999).

Referencias

Datasheet

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

Vista general

Imágenes

Referencias

Datasheet

SDS