Anti-Human GFR alpha-like Recombinant Antibody (25M22) (HS720107)

Name: Anti-Human GFR alpha-like Recombinant Antibody (25M22)
Brand: abinScience
SKU: HS720107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HS720107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	25M22
Clonality	Monoclonal
Target	C6orf144, GDNF family receptor alpha-like, GFRAL
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q6UXV0
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	GDNF family receptor alpha-like (GFRAL) is a ~44 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. 1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 5. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958 7. Li, J. et al. (2019) eLife 8. PMID: 31535977
Note	For research use only.

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Bioactivity

Detects GFRAL in indirect ELISAs.

References

Datasheet

Anti-Human GFR alpha-like Recombinant Antibody (25M22).pdf

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Anti-Human GFR alpha-like Recombinant Antibody (25M22) (HS720107)

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