Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

Name: Anti-Human GFR alpha-like Recombinant Antibody (SAA1999)
Brand: abinScience
SKU: HS720013
Price: 110 USD
Availability: InStock

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1mg

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HS720013

Description

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013) is a human monoclonal antibody detecting GFR alpha-like in ELISA, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, WB

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG1

ID de clone

SAA1999

Cible

C6orf144, GDNF family receptor alpha-like, GFRAL

Niveau d'endotoxines

< 10 EU/mg as determined by LAL method.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q6UXV0

RRID

Anti-Human GFRAL Antibody (SAA1999) (abinScience Cat# HS720013, RRID:AB_3727911)
_x005F_x000D_

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

GDNF family receptor alpha-like (GFRAL) is a ~44 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.

1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

5. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958

7. Li, J. et al. (2019) eLife 8. PMID: 31535977

Note

For research use only.

Isotype Control

Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

Images

SDS-PAGE

SDS-PAGE for Anti-Human GFRAL Antibody (SAA1999).

Reférences

Fiche technique

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

Aperçu

Images

Reférences

Fiche technique

SDS