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Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014)

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Aperçu
Numéro de catalogueHT027014
Description
Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014) is a rabbit polyclonal antibody detecting GluN2D. Suitable for Mouse, Rat, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human GluN2D/NR2D (Arg49-Tyr413).
Cible EB11, GRIN2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate receptor ionotropic, NMDA 2D, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès O15399
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Glutamate receptor ionotropic, NMDA 2D (GluN2D/NR2D) is a ~143 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626
2. Li, D. et al. (2016) American journal of human genetics 99, 802-816. PMID: 27616483
3. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851
4. Hess, SD. et al. (1998) Journal of neurochemistry 70, 1269-79. PMID: 9489750
5. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420
Note For research use only
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Reférences
Fiche technique
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human GluN2D/NR2D Polyclonal Antibody

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