Human GluN2D/NR2D Recombinant Protein (N-His) (HT027012)

Name: Human GluN2D/NR2D Recombinant Protein (N-His)
Brand: abinScience
SKU: HT027012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HT027012
Description	Recombinant Human GluN2D/NR2D Protein, N-His (HT027012) expressed in E. coli, spanning Arg49-Tyr413. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O15399
Protein length	Arg49-Tyr413
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	41.37 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EB11, GRIN2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate receptor ionotropic, NMDA 2D, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D
Background	Glutamate receptor ionotropic, NMDA 2D is a ~143 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626 2. Li, D. et al. (2016) American journal of human genetics 99, 802-816. PMID: 27616483 3. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851 4. Hess, SD. et al. (1998) Journal of neurochemistry 70, 1269-79. PMID: 9489750 5. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420
Note	For research use only

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Datasheet

Human GluN2D/NR2D Recombinant Protein (N-His).pdf

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Human GluN2D/NR2D Recombinant Protein (N-His) (HT027012)

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