Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014)

Name: Anti-Human GluN2D/NR2D Polyclonal Antibody
Brand: abinScience
SKU: HT027014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HT027014

Description

Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014) is a rabbit polyclonal antibody detecting GluN2D. Suitable for Mouse, Rat, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GluN2D/NR2D (Arg49-Tyr413).

Target

EB11, GRIN2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate receptor ionotropic, NMDA 2D, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O15399

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Glutamate receptor ionotropic, NMDA 2D (GluN2D/NR2D) is a ~143 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626

2. Li, D. et al. (2016) American journal of human genetics 99, 802-816. PMID: 27616483

3. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851

4. Hess, SD. et al. (1998) Journal of neurochemistry 70, 1269-79. PMID: 9489750

5. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420

Note

For research use only

Images

References

Datasheet

Anti-Human GluN2D/NR2D Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014)

Overview

Images

References

Datasheet

SDS

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