Anti-Human NMDAR1 Recombinant Antibody (#003-102) (HC465043)

Name: Anti-Human NMDAR1 Recombinant Antibody (#003-102)
Brand: abinScience
SKU: HC465043
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC465043

Reactividad de especies

Human, Rat

Aplicaciones

ELISA

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

IgG1, lambda

ID de clon

#003-102

Objetivo

Glutamate receptor ionotropic NMDA 1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, hNR1, GRIN1, NMDAR1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q05586

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Glutamate receptor ionotropic, NMDA 1 (GRIN1/NMDAR1) is a ~105 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Hamdan, FF. et al. (2011) American journal of human genetics 88, 306-16. PMID: 21376300

2. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626

3. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761

4. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851

5. Chen, W. et al. (2017) Journal of human genetics 62, 589-597. PMID: 28228639

6. Zhang, J. et al. (2023) Nature structural & molecular biology 30, 629-639. PMID: 36959261

7. Karp, SJ. et al. (1993) The Journal of biological chemistry 268, 3728-33. PMID: 7679115

8. Younkin, DP. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2174-8. PMID: 7681588

9. Planells-Cases, R. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 5057-61. PMID: 7685113

Nota

For research use only

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human GRIN1/NMDAR1 Antibody (#003-102)

Referencias

Datasheet

Anti-Human NMDAR1 Recombinant Antibody (#003-102).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo