Anti-Human GRIN1/NMDAR1 Polyclonal Antibody (HC465014)

Name: Anti-Human GRIN1/NMDAR1 Polyclonal Antibody
Brand: abinScience
SKU: HC465014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HC465014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GRIN1/NMDAR1 (Asp23-His371).

Target

N-methyl-D-aspartate receptor subunit NR1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic, NMDA 1, NMD-R1, GRIN1, NMDAR1

Purification

Purified by antigen affinity column.

Accession

Q05586

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Glutamate receptor ionotropic, NMDA 1 (GRIN1/NMDAR1) is a ~105 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Hamdan, FF. et al. (2011) American journal of human genetics 88, 306-16. PMID: 21376300

2. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626

3. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761

4. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851

5. Chen, W. et al. (2017) Journal of human genetics 62, 589-597. PMID: 28228639

6. Zhang, J. et al. (2023) Nature structural & molecular biology 30, 629-639. PMID: 36959261

7. Karp, SJ. et al. (1993) The Journal of biological chemistry 268, 3728-33. PMID: 7679115

8. Younkin, DP. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2174-8. PMID: 7681588

9. Planells-Cases, R. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 5057-61. PMID: 7685113

Note

For research use only.

Images

References

Datasheet

Anti-Human GRIN1/NMDAR1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human GRIN1/NMDAR1 Polyclonal Antibody (HC465014)

Overview

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Datasheet

SDS

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