Anti-Human Hepcidin Recombinant Antibody (SAA2725) (HX911023)

Name: Anti-Human Hepcidin Recombinant Antibody (SAA2725)
Brand: abinScience
SKU: HX911023
Price: 191 USD
Availability: InStock

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Número de catálogo	HX911023
Reactividad de especies	Human
Aplicaciones	ELISA
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	SAA2725
Objetivo	HAMP, HEPC, Hepc20, Hepc25, Hepcidin, Hepcidin-20, Hepcidin-25, LEAP-1, LEAP1, Liver-expressed antimicrobial peptide 1, PLTR, Putative liver tumor regressor
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P81172
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Hepcidin is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. 1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227 2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594 3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342 4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005
Nota	For research use only