Anti-Human HAMP/Hepcidin Reference Antibody (LY2787106, RUO) (HX911016)

Name: Anti-Human HAMP/Hepcidin Reference Antibody (LY2787106, RUO)
Brand: abinScience
SKU: HX911016
Price: 370 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HX911016

Description

Anti-Human HAMP/Hepcidin (LY2787106) (HX911016) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Species reactivity

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo, WB

Host species

Human

Isotype

IgG

Clone ID

LY2787106

Expression system

Mammalian cells

Clonality

Monoclonal

Tested applications

Target

Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP

Endotoxin level

Please contact the lab for this information.

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P81172

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

LY2787106

Background

Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227

2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594

3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342

4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin (LY2787106)
Bioactivity

Detects recombinant Hepcidin (Catalog No: HX911022) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-Hepcidin monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human Hepcidin (Catalog No: HX911022)
Lane 2: Negative control