Anti-Human HIF1A Monoclonal Antibody (1A713) (HS858025)

Name: Anti-Human HIF1A Monoclonal Antibody (1A713)
Brand: abinScience
SKU: HS858025
Price: 106 USD
Availability: InStock

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Numéro de catalogue	HS858025
Description	Anti-Human HIF1A Monoclonal Antibody (1A713) [1A713] (HS858025) is a mouse monoclonal antibody detecting HIF1A in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Reactivité des espèces	Human
Applications	ELISA, IHC, WB
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG
ID de clone	1A713
Immunogène	E. coli - derived recombinant human HIF1A (Asp55-Val342).
Cible	Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q16665
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Hypoxia-inducible factor 1-alpha (HIF1A) is a ~92 kDa protein. Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. 1. Jaakkola, P. et al. (2001) Science (New York, N.Y.) 292, 468-72. PMID: 11292861 2. Masson, N. et al. (2001) The EMBO journal 20, 5197-206. PMID: 11566883 3. Bae, SH. et al. (2004) Biochemical and biophysical research communications 324, 394-400. PMID: 15465032 4. Choi, SM. et al. (2006) The Journal of biological chemistry 281, 34056-63. PMID: 16973622 5. Berta, MA. et al. (2007) Biochemical and biophysical research communications 360, 646-52. PMID: 17610843 6. Kim, EJ. et al. (2008) Arteriosclerosis, thrombosis, and vascular biology 28, 1796-802. PMID: 18658046 7. Gimm, T. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 4443-58. PMID: 20624928 8. Shan, B. et al. (2012) Endocrine-related cancer 19, 13-27. PMID: 22009797 9. Xu, C. et al. (2018) PLoS pathogens 14, e1007259. PMID: 30125331 10. Bhattacharya, S. et al. (1999) Genes & development 13, 64-75. PMID: 9887100
Note	For research use only.