Anti-Human HMGB1 Monoclonal Antibody (1A068) (HY200025)

Name: Anti-Human HMGB1 Monoclonal Antibody (1A068)
Brand: abinScience
SKU: HY200025
Price: 106 USD
Availability: InStock

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Каталожный номер	HY200025
Описание	Anti-Human HMGB1 Monoclonal Antibody (1A068) [1A068] (HY200025) is a mouse monoclonal antibody detecting HMGB1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, IHC, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1
ID клона	1A068
Иммуноген	Mammalian cells - derived recombinant Human HMGB1 (Met1-Glu215).
Цель	High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1,
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P09429
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. 1. Wei, J. et al. (2021) Cell 184, 76-91.e13. PMID: 33147444 2. Avgousti, DC. et al. (2016) Nature 535, 173-7. PMID: 27362237 3. Wang, G. et al. (2021) Cell death discovery 7, 337. PMID: 34743181 4. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148 5. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706 6. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764 7. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472 8. Min, HJ. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1797-806. PMID: 23303669 9. Lee, LC. et al. (2014) PloS one 9, e115809. PMID: 25549101
Примечание	For research use only.

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Anti-Human HMGB1 Monoclonal Antibody (1A068).pdf

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Anti-Human HMGB1 Monoclonal Antibody (1A068) (HY200025)

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