Anti-Human HTR2B Polyclonal Antibody (HA694014)

Name: Anti-Human HTR2B Polyclonal Antibody
Brand: abinScience
SKU: HA694014
Price: 168 USD
Availability: InStock

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HA694014

Descripción

Anti-Human HTR2B Polyclonal Antibody (HA694014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B; HTR2B in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human HTR2B (Leu239-Val325).

Objetivo

5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B; HTR2B

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P41595

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

5-hydroxytryptamine receptor 2B (HTR2B) is a ~54 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.

1. Cussac, D. et al. (2008) European journal of pharmacology 594, 32-8. PMID: 18703043

2. Wang, C. et al. (2013) Science (New York, N.Y.) 340, 610-4. PMID: 23519210

3. Choi, DS. et al. (1994) FEBS letters 352, 393-9. PMID: 7926008

4. Kursar, JD. et al. (1994) Molecular pharmacology 46, 227-34. PMID: 8078486

5. Schmuck, K. et al. (1994) FEBS letters 342, 85-90. PMID: 8143856

6. Ullmer, C. et al. (1996) British journal of pharmacology 117, 1081-8. PMID: 8882600

7. Schaerlinger, B. et al. (2003) British journal of pharmacology 140, 277-84. PMID: 12970106

8. Wacker, D. et al. (2013) Science (New York, N.Y.) 340, 615-9. PMID: 23519215

10. Wacker, D. et al. (2017) Cell 168, 377-389.e12. PMID: 28129538

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human HTR2B Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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