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| カタログ番号 | HA694014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human HTR2B Polyclonal Antibody (HA694014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B; HTR2B in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human HTR2B (Leu239-Val325). | ||||||||
| ターゲット | 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B; HTR2B | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P41595 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 5-hydroxytryptamine receptor 2B (HTR2B) is a ~54 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. 1. Cussac, D. et al. (2008) European journal of pharmacology 594, 32-8. PMID: 18703043 2. Wang, C. et al. (2013) Science (New York, N.Y.) 340, 610-4. PMID: 23519210 3. Choi, DS. et al. (1994) FEBS letters 352, 393-9. PMID: 7926008 4. Kursar, JD. et al. (1994) Molecular pharmacology 46, 227-34. PMID: 8078486 5. Schmuck, K. et al. (1994) FEBS letters 342, 85-90. PMID: 8143856 6. Ullmer, C. et al. (1996) British journal of pharmacology 117, 1081-8. PMID: 8882600 7. Schaerlinger, B. et al. (2003) British journal of pharmacology 140, 277-84. PMID: 12970106 8. Wacker, D. et al. (2013) Science (New York, N.Y.) 340, 615-9. PMID: 23519215 10. Wacker, D. et al. (2017) Cell 168, 377-389.e12. PMID: 28129538 | ||||||||
| 注意事項 | For research use only |
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