

| Numéro de catalogue | HC684014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human HTR4 Polyclonal Antibody (HC684014) is a rabbit polyclonal antibody detecting HTR4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human HTR4 (Arg214-Thr260). | ||||||||
| Cible | HTR4, Serotonin receptor 4, 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q13639 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | 5-hydroxytryptamine receptor 4 (HTR4) is a ~43 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. 1. Mialet, J. et al. (2000) British journal of pharmacology 130, 527-38. PMID: 10821780 2. Kamel, R. et al. (2005) Biochemical pharmacology 70, 1009-18. PMID: 16102731 3. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614 4. Blondel, O. et al. (1998) Journal of neurochemistry 70, 2252-61. PMID: 9603189 | ||||||||
| Note | For research use only. |




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