Anti-Human IDE Recombinant Antibody (SAA1582) (HB619013)

Name: Anti-Human IDE Recombinant Antibody (SAA1582)
Brand: abinScience
SKU: HB619013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB619013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1582

Objetivo

Insulysin, IDE, Abeta-degrading protease, Insulin protease, Insulinase, Insulin-degrading enzyme

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P14735

RRID

Anti-Human IDE Antibody (SAA1582) (abinScience Cat# HB619013, RRID:AB_3727343)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Insulin-degrading enzyme (IDE) is a ~117 kDa protein. Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin. Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP.

1. Vekrellis, K. et al. (2000) The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 1657-65. PMID: 10684867

2. Shen, Y. et al. (2006) Nature 443, 870-4. PMID: 17051221

3. Im, H. et al. (2007) The Journal of biological chemistry 282, 25453-63. PMID: 17613531

4. Malito, E. et al. (2008) Biochemistry 47, 12822-34. PMID: 18986166

5. Manolopoulou, M. et al. (2009) The Journal of biological chemistry 284, 14177-88. PMID: 19321446

6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034

7. Affholter, JA. et al. (1990) Molecular endocrinology (Baltimore, Md.) 4, 1125-35. PMID: 2293021

8. McCord, LA. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 13827-32. PMID: 23922390

9. Maianti, JP. et al. (2014) Nature 511, 94-8. PMID: 24847884

10. Deprez-Poulain, R. et al. (2015) Nature communications 6, 8250. PMID: 26394692

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human IDE Antibody (SAA1582)

Referencias

Datasheet

Anti-Human IDE Recombinant Antibody (SAA1582).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo