Anti-Human IDE Recombinant Antibody (SAA1582) (HB619013)

Name: Anti-Human IDE Recombinant Antibody (SAA1582)
Brand: abinScience
SKU: HB619013
Price: 196 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) :

Spécification :

50ug
100ug
1mg

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HB619013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1582

Cible

Insulysin, IDE, Abeta-degrading protease, Insulin protease, Insulinase, Insulin-degrading enzyme

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P14735

RRID

Anti-Human IDE Antibody (SAA1582) (abinScience Cat# HB619013, RRID:AB_3727343)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Insulin-degrading enzyme (IDE) is a ~117 kDa protein. Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin. Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP.

1. Vekrellis, K. et al. (2000) The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 1657-65. PMID: 10684867

2. Shen, Y. et al. (2006) Nature 443, 870-4. PMID: 17051221

3. Im, H. et al. (2007) The Journal of biological chemistry 282, 25453-63. PMID: 17613531

4. Malito, E. et al. (2008) Biochemistry 47, 12822-34. PMID: 18986166

5. Manolopoulou, M. et al. (2009) The Journal of biological chemistry 284, 14177-88. PMID: 19321446

6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034

7. Affholter, JA. et al. (1990) Molecular endocrinology (Baltimore, Md.) 4, 1125-35. PMID: 2293021

8. McCord, LA. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 13827-32. PMID: 23922390

9. Maianti, JP. et al. (2014) Nature 511, 94-8. PMID: 24847884

10. Deprez-Poulain, R. et al. (2015) Nature communications 6, 8250. PMID: 26394692

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human IDE Antibody (SAA1582)

Reférences

Fiche technique

Anti-Human IDE Recombinant Antibody (SAA1582).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai