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| カタログ番号 | HB619013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1582 | ||||
| ターゲット | Insulysin, IDE, Abeta-degrading protease, Insulin protease, Insulinase, Insulin-degrading enzyme | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P14735 | ||||
| RRID | Anti-Human IDE Antibody (SAA1582) (abinScience Cat# HB619013, RRID:AB_3727343) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Insulin-degrading enzyme (IDE) is a ~117 kDa protein. Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin. Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP. 1. Vekrellis, K. et al. (2000) The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 1657-65. PMID: 10684867 2. Shen, Y. et al. (2006) Nature 443, 870-4. PMID: 17051221 3. Im, H. et al. (2007) The Journal of biological chemistry 282, 25453-63. PMID: 17613531 4. Malito, E. et al. (2008) Biochemistry 47, 12822-34. PMID: 18986166 5. Manolopoulou, M. et al. (2009) The Journal of biological chemistry 284, 14177-88. PMID: 19321446 6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034 7. Affholter, JA. et al. (1990) Molecular endocrinology (Baltimore, Md.) 4, 1125-35. PMID: 2293021 8. McCord, LA. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 13827-32. PMID: 23922390 9. Maianti, JP. et al. (2014) Nature 511, 94-8. PMID: 24847884 10. Deprez-Poulain, R. et al. (2015) Nature communications 6, 8250. PMID: 26394692 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human IDE Antibody (SAA1582)
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中国武漢市深敦寺路666号C棟、武漢、430206
