Anti-Human IFN-alpha/beta R1 Recombinant Antibody (64G12) (HB823013)

Name: Anti-Human IFN-alpha/beta R1 Recombinant Antibody (64G12)
Brand: abinScience
SKU: HB823013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB823013

Reactividad de especies

Human

Aplicaciones

ELISA, SPR

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG1, kappa

ID de clon

64G12

Objetivo

IFNAR1, Interferon alpha/beta receptor 1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P17181

RRID

Anti-Human IFNAR1 Antibody (64G12) (abinScience Cat# HB823013, RRID:AB_3727131)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Interferon alpha/beta receptor 1 (IFNAR1) is a ~63 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.

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2. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120

3. Kumar, KG. et al. (2004) The Journal of biological chemistry 279, 46614-20. PMID: 15337770

4. Uzé, G. et al. (1990) Cell 60, 225-34. PMID: 2153461

5. Thomas, C. et al. (2011) Cell 146, 621-32. PMID: 21854986

6. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

7. Hernandez, N. et al. (2019) The Journal of experimental medicine 216, 2057-2070. PMID: 31270247

8. Gothe, F. et al. (2022) Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 74, 136-139. PMID: 33252644

9. Bastard, P. et al. (2022) The Journal of experimental medicine 219. PMID: 35442418

10. Abramovich, C. et al. (1994) The EMBO journal 13, 5871-7. PMID: 7813427

Nota

For research use only.

Imágenes