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| カタログ番号 | HY471014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IGFBP1 Polyclonal Antibody (HY471014) is a rabbit polyclonal antibody detecting IGFBP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IGFBP1 (Ala26-Asn259). | ||||||||
| ターゲット | IGFBP-1, IGFBP1, Insulin-like growth factor-binding protein 1, Placental protein 12, IBP1, IGF-binding protein 1, IBP-1, PP12 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P08833 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Insulin-like growth factor-binding protein 1 (IGFBP1) is a ~27 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation. 1. Gleeson, LM. et al. (2001) The Journal of clinical endocrinology and metabolism 86, 2484-93. PMID: 11397844 2. Sala, A. et al. (2005) The Journal of biological chemistry 280, 29812-9. PMID: 15972819 3. Jones, JI. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 10553-7. PMID: 7504269 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-IGFBP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
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