Anti-Human IGFBP-1 Monoclonal Antibody (1A111) (HY471085)

Name: Anti-Human IGFBP-1 Monoclonal Antibody (1A111)
Brand: abinScience
SKU: HY471085
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HY471085
Description	Anti-Human IGFBP1 Monoclonal Antibody (1A111) [1A111] (HY471085) is a mouse monoclonal antibody detecting IGFBP1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG1
Clone ID	1A111
Immunogen	Mammalian cells - derived recombinant Human IGFBP1 (Met1-Asn259).
Target	IGFBP-1, IGFBP1, Insulin-like growth factor-binding protein 1, Placental protein 12, IBP1, IGF-binding protein 1, IBP-1, PP12,
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08833
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Insulin-like growth factor-binding protein 1 (IGFBP1) is a ~29 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation.
Note	For research use only.

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Datasheet

Anti-Human IGFBP-1 Monoclonal Antibody (1A111).pdf

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Anti-Human IGFBP-1 Monoclonal Antibody (1A111) (HY471085)

Overview

Images

References

Datasheet

SDS