Anti-Human IGFBP3 Recombinant Antibody (SAA1589) (HB776013)

Name: Anti-Human IGFBP3 Recombinant Antibody (SAA1589)
Brand: abinScience
SKU: HB776013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB776013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1589

Objetivo

IBP-3, Insulin-like growth factor-binding protein 3, IGF-binding protein 3, IBP3, IGFBP-3, IGFBP3

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P17936

RRID

Anti-Human IGFBP3 Antibody (SAA1589) (abinScience Cat# HB776013, RRID:AB_3727350)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Insulin-like growth factor-binding protein 3 (IGFBP3) is a ~31 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1.

1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 10874028

2. Cobb, LJ. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 1624-33. PMID: 19556345

3. Ingermann, AR. et al. (2010) The Journal of biological chemistry 285, 30233-46. PMID: 20353938

4. Muzumdar, RH. et al. (2009) PloS one 4, e6334. PMID: 19623253

5. Lue, Y. et al. (2010) Endocrinology 151, 350-7. PMID: 19952275

6. Leal, SM. et al. (1997) The Journal of biological chemistry 272, 20572-6. PMID: 9252371

7. Huang, SS. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1719-21. PMID: 15371331

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human IGFBP3 Antibody (SAA1589)

Referencias

Datasheet

Anti-Human IGFBP3 Recombinant Antibody (SAA1589).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo