Anti-IGFBP3 Polyclonal Antibody (HB776014)

Name: Anti-IGFBP3 Polyclonal Antibody
Brand: abinScience
SKU: HB776014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB776014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IGFBP3 (Gly135-Thr277).

Target

IBP-3, Insulin-like growth factor-binding protein 3, IGF-binding protein 3, IBP3, IGFBP-3, IGFBP3

Purification

Purified by antigen affinity column.

Accession

P17936

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Insulin-like growth factor-binding protein 3 (IGFBP3) is a ~31 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1.

1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 10874028

2. Cobb, LJ. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 1624-33. PMID: 19556345

3. Ingermann, AR. et al. (2010) The Journal of biological chemistry 285, 30233-46. PMID: 20353938

4. Muzumdar, RH. et al. (2009) PloS one 4, e6334. PMID: 19623253

5. Lue, Y. et al. (2010) Endocrinology 151, 350-7. PMID: 19952275

6. Leal, SM. et al. (1997) The Journal of biological chemistry 272, 20572-6. PMID: 9252371

7. Huang, SS. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1719-21. PMID: 15371331

Note

For research use only.

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