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| カタログ番号 | HB776013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1589 | ||||
| ターゲット | IBP-3, Insulin-like growth factor-binding protein 3, IGF-binding protein 3, IBP3, IGFBP-3, IGFBP3 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P17936 | ||||
| RRID | Anti-Human IGFBP3 Antibody (SAA1589) (abinScience Cat# HB776013, RRID:AB_3727350) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Insulin-like growth factor-binding protein 3 (IGFBP3) is a ~31 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1. 1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 10874028 2. Cobb, LJ. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 1624-33. PMID: 19556345 3. Ingermann, AR. et al. (2010) The Journal of biological chemistry 285, 30233-46. PMID: 20353938 4. Muzumdar, RH. et al. (2009) PloS one 4, e6334. PMID: 19623253 5. Lue, Y. et al. (2010) Endocrinology 151, 350-7. PMID: 19952275 6. Leal, SM. et al. (1997) The Journal of biological chemistry 272, 20572-6. PMID: 9252371 7. Huang, SS. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1719-21. PMID: 15371331 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human IGFBP3 Antibody (SAA1589)
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