Anti-Human IL-15 Recombinant Antibody (SAA2391) (HW541013)

Name: Anti-Human IL-15 Recombinant Antibody (SAA2391)
Brand: abinScience
SKU: HW541013
Price: 126 USD
Availability: InStock

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20ug
50ug
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1mg

Número:

Contáctenos

Vista general
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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HW541013

Reactividad de especies

Human

Aplicaciones

ELISA

Clonalidad

Monoclonal

Isotipo

SCFV-mFc

ID de clon

SAA2391

Objetivo

Interleukin-15, IL-15, IL15

Nivel de endotoxinas

<10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P40933

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Fondo

Interleukin-15 (IL15) is a ~18 kDa protein. Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5.

1. Ratthé, C. et al. (2004) Journal of leukocyte biology 76, 162-8. PMID: 15123770

2. Grabstein, KH. et al. (1994) Science (New York, N.Y.) 264, 965-8. PMID: 8178155

3. Badolato, R. et al. (1997) Blood 90, 2804-9. PMID: 9326248

4. Musso, T. et al. (1999) Blood 93, 3531-9. PMID: 10233906

5. Ring, AM. et al. (2012) Nature immunology 13, 1187-95. PMID: 23104097

6. Giri, JG. et al. (1994) The EMBO journal 13, 2822-30. PMID: 8026467

7. Johnston, JA. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8705-9. PMID: 7568001

Nota

For research use only

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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