Research Grade Inbakicept (HW541026)

Name: Research Grade Inbakicept
Brand: abinScience
SKU: HW541026
Price: 424 USD
Availability: InStock

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Overview

Catalog No.	HW541026
Description	Inbakicept (HW541026) is a research-grade recombinant antibody targeting IL15. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Fusion - [IL15RA (interleukin 15 receptor subunit alpha, CD215, IL-15RA)]2 - IGHG1 Fc (Fragment constant)
Expression system	Mammalian cells
Target	IL15, IL-15, Interleukin-15
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P40933
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ALT-803(=inbakiceptINN11029([IL15RA]2-Fc)incomplex1:2withnogapendekinalfaINN11157(IL15D72)), [IL15RA]2-Fc, 2135939-52-3
Background	Interleukin-15 (IL15) is a ~18 kDa protein. Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. 1. Ratthé, C. et al. (2004) Journal of leukocyte biology 76, 162-8. PMID: 15123770 2. Grabstein, KH. et al. (1994) Science (New York, N.Y.) 264, 965-8. PMID: 8178155 3. Badolato, R. et al. (1997) Blood 90, 2804-9. PMID: 9326248 4. Musso, T. et al. (1999) Blood 93, 3531-9. PMID: 10233906 5. Ring, AM. et al. (2012) Nature immunology 13, 1187-95. PMID: 23104097 6. Giri, JG. et al. (1994) The EMBO journal 13, 2822-30. PMID: 8026467 7. Johnston, JA. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8705-9. PMID: 7568001
Note	For research use only. Not suitable for clinical or therapeutic use.