Anti-Human IL15 Recombinant Antibody (SAA0384), FITC (HW541117)

Name: Anti-Human IL15 Recombinant Antibody (SAA0384), FITC
Brand: abinScience
SKU: HW541117
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HW541117
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	SAA0384
Conjugation	FITC
Clonality	Monoclonal
Target	IL15, IL-15, Interleukin-15
Endotoxin level	Please contact with the lab for this information.
Accession	P40933
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Interleukin-15 (IL15) is a ~18 kDa protein. Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. 1. Ratthé, C. et al. (2004) Journal of leukocyte biology 76, 162-8. PMID: 15123770 2. Grabstein, KH. et al. (1994) Science (New York, N.Y.) 264, 965-8. PMID: 8178155 3. Badolato, R. et al. (1997) Blood 90, 2804-9. PMID: 9326248 4. Musso, T. et al. (1999) Blood 93, 3531-9. PMID: 10233906 5. Ring, AM. et al. (2012) Nature immunology 13, 1187-95. PMID: 23104097 6. Giri, JG. et al. (1994) The EMBO journal 13, 2822-30. PMID: 8026467 7. Johnston, JA. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8705-9. PMID: 7568001
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.