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Каталожный номерHP148014
Описание
Anti-Human ING4 Polyclonal Antibody (HP148014) is a rabbit polyclonal antibody detecting ING4 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Chicken.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Реактивность видовHuman, Mouse
ПримененияELISA, IHC, WB
Хозяинский видRabbit
КлоональностьPolyclonal
ИзотипIgG
Иммуноген E. coli - derived recombinant Human ING4 (Met1-Lys127).
Цель ING4, Inhibitor of growth protein 4, p29ING4
Очистка Purified by antigen affinity column.
Номер доступа Q9UNL4
Форма Liquid
Буфер хранения 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта
Применение Разбавление
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

Inhibitor of growth protein 4 (ING4) is a ~28 kDa protein. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC.

1. Doyon, Y. et al. (2006) Molecular cell 21, 51-64. PMID: 16387653
2. Zhang, X. et al. (2004) FEBS letters 570, 7-12. PMID: 15251430
3. Kim, S. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 16251-6. PMID: 15528276
4. Garkavtsev, I. et al. (2004) Nature 428, 328-32. PMID: 15029197
5. Ozer, A. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 7481-6. PMID: 15897452
Примечание For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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