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| カタログ番号 | HP060025 |
|---|---|
| 説明 |
Anti-Human INPP5D Monoclonal Antibody (1A541) [1A541] (HP060025) is a mouse monoclonal antibody detecting INPP5D in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, IHC, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | 1A541 |
| 免疫原 | E. coli - derived recombinant human INPP5D (Pro298-Gly711). |
| ターゲット | Phosphatidylinositol 345-trisphosphate 5-phosphatase 1, EC:3.1.3.86, Inositol polyphosphate-5-phosphatase D, EC:3.1.3.56, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, Phosphatidylinositol 45-bisphosphate 5-phosphatase, EC:3.1.3.36, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q92835 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) is a ~133 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. 1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 10764818 2. Kavanaugh, WM. et al. (1996) Current biology : CB 6, 438-45. PMID: 8723348 3. Drayer, AL. et al. (1996) Biochemical and biophysical research communications 225, 243-9. PMID: 8769125 4. Odai, H. et al. (1997) Blood 89, 2745-56. PMID: 9108392 5. Vaillancourt, M. et al. (2006) Cellular signalling 18, 2022-32. PMID: 16682172 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human INPP5D Monoclonal Antibody (1A541)
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