Anti-Human INPP5D Polyclonal Antibody (HP060014)

Name: Anti-Human INPP5D Polyclonal Antibody
Brand: abinScience
SKU: HP060014
Price: 168 USD
Availability: InStock

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Overview
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SDS

Overview

Catalog No.

HP060014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human INPP5D (Pro298-Gly711).

Target

Inositol polyphosphate-5-phosphatase D, p150Ship, hp51CN, INPP5D, SH2 domain-containing inositol 5'-phosphatase 1, SHIP, SHIP1, Phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 1, SHIP-1, SIP-145, Phosphatidylinositol 4, 5-bisphosphate 5-phosphatase, SH2 domain-containing inositol phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa

Purification

Purified by antigen affinity column.

Accession

Q92835

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) is a ~133 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells.

1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 10764818

2. Kavanaugh, WM. et al. (1996) Current biology : CB 6, 438-45. PMID: 8723348

3. Drayer, AL. et al. (1996) Biochemical and biophysical research communications 225, 243-9. PMID: 8769125

4. Odai, H. et al. (1997) Blood 89, 2745-56. PMID: 9108392

5. Vaillancourt, M. et al. (2006) Cellular signalling 18, 2022-32. PMID: 16682172

Note

For research use only.

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References

Datasheet