Anti-Human INPP5D Monoclonal Antibody (1A541) (HP060025)

Name: Anti-Human INPP5D Monoclonal Antibody (1A541)
Brand: abinScience
SKU: HP060025
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HP060025
Description	Anti-Human INPP5D Monoclonal Antibody (1A541) [1A541] (HP060025) is a mouse monoclonal antibody detecting INPP5D in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG
Clone ID	1A541
Immunogen	E. coli - derived recombinant human INPP5D (Pro298-Gly711).
Target	Phosphatidylinositol 345-trisphosphate 5-phosphatase 1, EC:3.1.3.86, Inositol polyphosphate-5-phosphatase D, EC:3.1.3.56, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, Phosphatidylinositol 45-bisphosphate 5-phosphatase, EC:3.1.3.36, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q92835
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) is a ~133 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. 1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 10764818 2. Kavanaugh, WM. et al. (1996) Current biology : CB 6, 438-45. PMID: 8723348 3. Drayer, AL. et al. (1996) Biochemical and biophysical research communications 225, 243-9. PMID: 8769125 4. Odai, H. et al. (1997) Blood 89, 2745-56. PMID: 9108392 5. Vaillancourt, M. et al. (2006) Cellular signalling 18, 2022-32. PMID: 16682172
Note	For research use only.