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| カタログ番号 | HP466014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ITCH Polyclonal Antibody (HP466014) is a rabbit polyclonal antibody detecting ITCH in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ITCH (Met1-Gly141). | ||||||||
| ターゲット | Atrophin-1-interacting protein 4, HECT-type E3 ubiquitin transferase Itchy homolog, NFE2-associated polypeptide 1, NAPP1, E3 ubiquitin-protein ligase Itchy homolog, ITCH, Itch, AIP4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96J02 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase Itchy homolog is a ~102 kDa protein. Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. Involved in the control of inflammatory signaling pathways. Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. 1. Winberg, G. et al. (2000) Molecular and cellular biology 20, 8526-35. PMID: 11046148 2. Marchese, A. et al. (2003) Developmental cell 5, 709-22. PMID: 14602072 3. Feng, L. et al. (2004) The Journal of biological chemistry 279, 29681-90. PMID: 15051726 4. Yang, C. et al. (2006) Molecular cell 21, 135-41. PMID: 16387660 5. Chastagner, P. et al. (2006) EMBO reports 7, 1147-53. PMID: 17028573 6. Lee, TL. et al. (2008) Biochemical and biophysical research communications 375, 326-30. PMID: 18718448 7. Scialpi, F. et al. (2008) Biochemical pharmacology 76, 1515-21. PMID: 18718449 8. Bhandari, D. et al. (2009) Molecular biology of the cell 20, 1324-39. PMID: 19116316 9. Tao, M. et al. (2009) Current biology : CB 19, 1255-63. PMID: 19592251 10. You, F. et al. (2009) Nature immunology 10, 1300-8. PMID: 19881509 | ||||||||
| 注意事項 | For research use only. |
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