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| カタログ番号 | HB878014 | ||||||||
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| 説明 |
Anti-Human ITGB7 Polyclonal Antibody (HB878014) is a rabbit polyclonal antibody detecting ITGB7 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ITGB7 (Tyr150-Thr392). | ||||||||
| ターゲット | Integrin beta-7, Gut homing receptor beta subunit, ITGB7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26010 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Integrin beta-7 (ITGB7) is a ~86 kDa protein. Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). 1. Higgins, JM. et al. (2000) The Journal of biological chemistry 275, 25652-64. PMID: 10837471 2. Chen, J. et al. (2003) Nature structural biology 10, 995-1001. PMID: 14608374 | ||||||||
| 注意事項 | For research use only. |
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