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| カタログ番号 | HP634013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1 | ||||
| クローンID | SAA0203 | ||||
| ターゲット | Histone arginine demethylase JMJD6, Phosphatidylserine receptor, JmjC domain-containing protein 6, JMJD6, PTDSR, PSR, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Jumonji domain-containing protein 6, Protein PTDSR, Peptide-lysine 5-dioxygenase JMJD6, Lysyl-hydroxylase JMJD6, KIAA0585 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q6NYC1 | ||||
| RRID | Anti-Human JMJD6 IP Antibody (SAA0203) (abinScience Cat# HP634013, RRID:AB_3729737) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is a ~46 kDa protein. Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting. 1. Chang, B. et al. (2007) Science (New York, N.Y.) 318, 444-7. PMID: 17947579 2. Mantri, M. et al. (2010) Journal of molecular biology 401, 211-22. PMID: 20684070 3. Hahn, P. et al. (2010) PloS one 5, e13769. PMID: 21060799 4. Han, G. et al. (2012) Journal of cellular biochemistry 113, 1663-70. PMID: 22189873 5. Poulard, C. et al. (2014) PloS one 9, e87982. PMID: 24498420 6. Webby, CJ. et al. (2009) Science (New York, N.Y.) 325, 90-3. PMID: 19574390 7. Hong, X. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 14568-72. PMID: 20679243 8. Konuma, T. et al. (2017) Scientific reports 7, 16272. PMID: 29176719 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human JMJD6 IP Antibody (SAA0203)
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