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| カタログ番号 | HP281014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KAT8 (Glu158-Lys432). | ||||||||
| ターゲット | MYST-1, hMOF, Histone acetyltransferase KAT8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, KAT8, MYST1, MOF, Lysine acetyltransferase 8 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H7Z6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Histone acetyltransferase KAT8 is a ~52 kDa protein. Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context. Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. 1. Pardo, PS. et al. (2002) The Journal of biological chemistry 277, 50860-6. PMID: 12397079 2. Smith, ER. et al. (2005) Molecular and cellular biology 25, 9175-88. PMID: 16227571 3. Mendjan, S. et al. (2006) Molecular cell 21, 811-23. PMID: 16543150 4. Cai, Y. et al. (2010) The Journal of biological chemistry 285, 4268-72. PMID: 20018852 5. Kadlec, J. et al. (2011) Nature structural & molecular biology 18, 142-9. PMID: 21217699 6. Yuan, H. et al. (2012) The EMBO journal 31, 58-70. PMID: 22020126 7. Huang, J. et al. (2012) Cell research 22, 1078-81. PMID: 22547026 8. Li, L. et al. (2020) The Journal of clinical investigation 130, 1431-1445. PMID: 31794431 9. Monserrat, J. et al. (2021) Nature cell biology 23, 401-412. PMID: 33837287 | ||||||||
| 注意事項 | For research use only. |
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