Anti-Human KAT8 Polyclonal Antibody (HP281014)

Name: Anti-Human KAT8 Polyclonal Antibody
Brand: abinScience
SKU: HP281014
Price: 168 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

50ug
100ug

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HP281014

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human KAT8 (Glu158-Lys432).

Цель

MYST-1, hMOF, Histone acetyltransferase KAT8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, KAT8, MYST1, MOF, Lysine acetyltransferase 8

Очистка

Purified by antigen affinity column.

Номер доступа

Q9H7Z6

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Histone acetyltransferase KAT8 is a ~52 kDa protein. Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context. Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome.

1. Pardo, PS. et al. (2002) The Journal of biological chemistry 277, 50860-6. PMID: 12397079

2. Smith, ER. et al. (2005) Molecular and cellular biology 25, 9175-88. PMID: 16227571

3. Mendjan, S. et al. (2006) Molecular cell 21, 811-23. PMID: 16543150

4. Cai, Y. et al. (2010) The Journal of biological chemistry 285, 4268-72. PMID: 20018852

5. Kadlec, J. et al. (2011) Nature structural & molecular biology 18, 142-9. PMID: 21217699

6. Yuan, H. et al. (2012) The EMBO journal 31, 58-70. PMID: 22020126

7. Huang, J. et al. (2012) Cell research 22, 1078-81. PMID: 22547026

8. Li, L. et al. (2020) The Journal of clinical investigation 130, 1431-1445. PMID: 31794431

9. Monserrat, J. et al. (2021) Nature cell biology 23, 401-412. PMID: 33837287

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human KAT8 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа