Anti-Human KCNB1 Polyclonal Antibody (HC581014)

Name: Anti-Human KCNB1 Polyclonal Antibody
Brand: abinScience
SKU: HC581014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Datasheet
SDS

Vista general

Número de catálogo

HC581014

Descripción

Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014) is a rabbit polyclonal antibody detecting KCNB1. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human KCNB1/Kv2.1 (Glu19-Val186).

Objetivo

DRK1, Delayed rectifier potassium channel 1, KCNB1, Potassium voltage-gated channel subfamily B member 1, Voltage-gated potassium channel subunit Kv2.1, h-DRK1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by antigen affinity column.

Número de acceso

Q14721

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

Potassium voltage-gated channel subfamily B member 1 (KCNB1/Kv2.1) is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.

1. Li, XN. et al. (2013) The Journal of pharmacology and experimental therapeutics 344, 407-16. PMID: 23161216

2. Shepard, AR. et al. (1999) The American journal of physiology 277, C412-24. PMID: 10484328

3. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 12560340

4. Ikeda, SR. et al. (1992) Pflugers Archiv : European journal of physiology 422, 201-3. PMID: 1283219

5. Mederos Y Schnitzler, M. et al. (2009) The Journal of biological chemistry 284, 4695-704. PMID: 19074135

6. Bocksteins, E. et al. (2009) The Journal of biological chemistry 284, 31625-34. PMID: 19717558

7. Bocksteins, E. et al. (2014) PloS one 9, e98960. PMID: 24901643

8. Albrecht, B. et al. (1993) Receptors & channels 1, 99-110. PMID: 8081723

9. Sano, Y. et al. (2002) FEBS letters 512, 230-4. PMID: 11852086

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human KCNB1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human KCNB1 Polyclonal Antibody (HC581014)

Vista general

Imágenes

Referencias

Datasheet

SDS